Preferred Label : Pegylated Liposomal Mitoxantrone Hydrochloride;
NCIt definition : A pegylated liposomal mitoxantrone formulation composed of the hydrochloride salt
form of the anthracenedione antibiotic mitoxantrone encapsulated within pegylated
small unilamellar vesicles (SUVs), with potential antineoplastic activity. Upon intravenous
administration, mitoxantrone intercalates into and forms crosslinks with DNA, thereby
disrupting DNA and RNA replication. This agent also binds to topoisomerase II, which
both results in DNA strand breaks and prevents DNA synthesis. This leads to the induction
of apoptosis in rapidly dividing cancer cells. The pegylated liposomal formulation
improves drug penetration into tumors and decreases drug clearance, thereby increasing
drug circulation and therapeutic efficacy while lowering toxic effects.;
Molecule name : PLM60;
NCI Metathesaurus CUI : CL514320;
Origin ID : C131307;
UMLS CUI : C4330974;
Manual NTBT mappings (CISMeF)
- Semantic type(s)
- concept_is_in_subset
