" /> Anti-HA Epitope Monoclonal Antibody MEDI8852 - CISMeF





Preferred Label : Anti-HA Epitope Monoclonal Antibody MEDI8852;

NCIt synonyms : pan-Influenza A mAb MEDI8852; Anti-Influenza A Hemagglutinin Epitope mAb MEDI8852;

NCIt related terms : MEDI-8852;

NCIt definition : A human immunoglobulin (Ig) G1 kappa monoclonal antibody (mAb) targeting a unique epitope in the stalk of the influenza A hemagglutinin (HA) protein, with broad influenza A virus neutralization activity. MEDI8852 was derived from an antibody isolated from human memory B-cells from patients previously infected with influenza caused by type A strains that was further optimized to increase neutralization potential. Upon infusion, MEDI8852 targets and binds to a region within the stalk of the HA protein that is highly conserved amongst all influenza A virus subtypes. This neutralizes and prevents essential steps of the viral lifecycle, thereby blocking infectivity of all influenza A virus subtypes. HA, a glycoprotein found on the surface of the influenza virus, plays a key role in viral attachment and cell entry.;

UNII : OZS4TXB9VO;

Molecule name : MEDI-8852; MEDI 8852;

NCI Metathesaurus CUI : CL514244;

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12/05/2024


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