Preferred Label : 2-Fluorofucose;
NCIt synonyms : 2-FF Containing SGN-2FF; 2FF-containing SGN-2FF;
NCIt definition : An orally bioavailable fluorinated analog of fucose that is a protein fucosylation
inhibitor, with potential antineoplastic and immunomodulating activities. Upon administration,
2-fluorofucose (2-FF) mimics fucose and is converted to guanosine diphosphate (GDP)-2FF,
which prevents the formation of the fucosylation substrate GDP-fucose, and the incorporation
of fucose into glycoproteins by fucosyltransferase. As fucosylation of glycoproteins
plays a key role in many biological processes, such as protein function, receptor
binding, cell signaling and cellular adhesion, and is essential for tumor progression,
blocking fucosylation decreases tumor cell growth. In addition, blocking fucosylation
of monoclonal antibodies generates fucose-deficient antibodies that exert enhanced
antibody-dependent cell-mediated cytotoxicity (ADCC).;
UNII : W39886N0ZG;
CAS number : 70763-62-1;
Molecule name : SGN-2FF;
NCI Metathesaurus CUI : CL514470;
Origin ID : C131289;
UMLS CUI : C5139675;
Semantic type(s)
- concept_is_in_subset
