Preferred Label : Carbon C14 EGFR Inhibitor ASP8273;
NCIt synonyms : 14C EGFR Inhibitor ASP8273; [14C] EGFR Inhibitor ASP8273; 14C ASP8273; [14C]ASP8273;
NCIt definition : A radioconjugate composed of ASP8273, an orally available, third-generation, mutant-selective,
irreversible epidermal growth factor receptor (EGFR) inhibitor, labeled with the radioisotope
carbon C 14, with potential use for evaluating the pharmacokinetic profile of ASP8273
during positron emission tomography (PET). Upon administration of carbon C 14 ASP8273,
ASP8273 targets, covalently binds to and inhibits the activity of mutant forms of
EGFR, including the T790M mutant form. Labeling of ASP8273 with the radioactive tracer
carbon C 14 permits the evaluation of this agent's pharmacokinetic profile, including
its absorption, distribution, metabolism, and excretion (ADME) using PET.;
NCI Metathesaurus CUI : CL514486;
Origin ID : C131288;
UMLS CUI : C4329619;
Semantic type(s)
- concept_is_in_subset
- has_target
