Preferred Label : Fluorine F18 T807;
Obsolete resource : true;
NCIt synonyms : [F18]T807; [(18)F]T807; Fluorine-18 Labeled 7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole; [18F]T807; 18F-AV-1451; F 18 T807;
NCIt definition : A radioconjugate composed of the paired helical filament (PHF) tau binding agent T807,
a benzimidazole pyrimidine derivative, conjugated to the radioisotope fluorine F 18,
with potential tau positron emission tomography (PET) imaging activity. Upon administration
of fluorine F18 T807, the T807 moiety targets and binds to PHF-tau in the brain, which
allows PET imaging of PHF-tau and analysis of phosphorylated PHF-tau aggregates (neurofibrillary
tangles). Increased levels of PHF-tau and neurofibrillary tangles are correlated with
the cognitive decline seen in neurodegenerative diseases, such as dementia, Alzheimer's
disease (AD) and chemotherapy-induced cognitive impairment (CICI).;
NCIt note : See 'Flortaucipir F-18(C171887)';
Concept status : Retired_Concept;
NCI Metathesaurus CUI : CL513090;
Origin ID : C131212;
UMLS CUI : C4547427;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
