Carbon C 11 Pittsburgh Compound B

Preferred Label : Carbon C 11 Pittsburgh Compound B;

NCIt synonyms : [11C]PiB; 11 Carbon Pittsburgh Compound B; [N-methyl-11C]2-(4'-methylaminophenyl)-6-hydroxybenzothiazole; 11C-PIB; C11-PiB; C11 Pittsburgh Compound B;

NCIt definition : A radioconjugate composed of the beta-amyloid binding agent Pittsburgh compound B (PiB), a derivative of the amyloid-binding dye thioflavin T (ThT), that is conjugated to the radioisotope carbon C11, with potential amyloid imaging activity upon positron emission tomography (PET). Upon administration of carbon C 11 PiB, the PiB moiety targets and binds to beta-amyloid plaques in the brain, which can then be detected and analyzed using PET imaging. Increased production and concentration of amyloid beta protein and the deposition of amyloid plaques in the brain are correlated with the cognitive decline seen in neurodegenerative diseases, such as dementia, Alzheimer's disease (AD) and chemotherapy-induced cognitive impairment (CICI).;

NCI Metathesaurus CUI : CL514003;

Details

Origin ID

C131211;

UMLS CUI

C1568156;

Automatic exact mappings (from CISMeF team)
- 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- ((11)C)PIB [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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