Preferred Label : Recombinant Human Bone Morphogenetic Protein 4;
NCIt synonyms : hrBMP-4; Recombinant Human BMP4; hrBMP4;
NCIt related terms : HUMAN RECOMBINANT BONE MORPHOGENETIC PROTEIN 4;
NCIt definition : A recombinant form of human bone morphogenetic protein 4 (rhBMP4; rhBMP-4), with potential
antineoplastic activity. Upon administration, rhBMP4 binds to BMP receptors (BMPRs)
and activates BMP-mediated signal transduction pathways. This may lead to the transcription
of BMP4-target genes and to inhibition of the proliferation of certain tumor cell
types. Additionally, rhBMP4 binding promotes the differentiation of normal stem cells
and decreases both differentiation and renewal of cancer stem cells (CSCs). BMP4,
an extracellular signaling molecule belonging to the transforming growth factor beta
(TGFb) superfamily, plays a key role in bone formation. It also plays a role in the
pathogenesis of certain cancers; BMP4 suppresses growth of certain types of cancer
cells, and is also able to induce migration, invasion, and epithelial-mesenchymal
transition (EMT), which may promote cancer metastasis and progression.;
UNII : 08RQ4CQ601;
NCI Metathesaurus CUI : CL514072;
Origin ID : C131018;
UMLS CUI : C4331223;
Semantic type(s)
- concept_is_in_subset
