Oprelvekin - CISMeF

Preferred Label : Oprelvekin;

NCIt synonyms : Recombinant Interleukin-11; Interleukin-11; Interleukin 11; Recombinant Human Interleukin-11; Interleukin-11-Recombinant; rhIL-11; IL-11; Adipogenesis Inhibitory Factor; Therapeutic Interleukin-11;

NCIt related terms : Neumega;

NCIt definition : A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin 11 (IL-11). Secreted by bone marrow stromal cells and a number of mesenchymal cells, IL-11 binds to and activates its cell-surface receptor, promoting primary and secondary immune responses, modulating antigen-specific antibody reactions, and preventing apoptotic cell death. This agent also stimulates the T-cell-dependent development of IgG-secreting B-cells in spleen cell cultures and may be an important regulator of megakaryocytopoiesis. (NCI04);

Alternative definition : NCI-GLOSS: A drug used to increase the number of blood cells, especially platelets, in some cancer patients receiving chemotherapy. Neumega is a form of interleukin-11 (a cytokine normally made by support cells in the bone marrow) that is made in the laboratory. It is a type of biological response modifier.;

UNII : HM5641GA6F;

CAS number : 145941-26-0;

Drug name : Neumega;

Codes from synonyms : CDR0000520411; CDR0000580275; CDR0000580234; CDR0000580268; 372;

Details

Origin ID

C1303;

UMLS CUI

C0537670;

False automatic mappings
- Informing [ICNP action]
- Informing (procedure) [SNOMED CT concept]
- duty to warn [MeSH Descriptor]
- research report [MeSH Descriptor]
See also inter- (CISMeF)
- Product containing oprelvekin (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Informing [ICNP action]
- Oprelvekin (substance) [SNOMED CT concept]
- Product containing oprelvekin (medicinal product) [SNOMED CT concept]
- oprelvekin [ATC Code]
- oprelvekin [MeSH Supplementary Concept]
- oprelvekin [MeSH concept]
Validated automatic mappings to BTNT
- oprelvekin [ATC Code]
Validated automatic mappings to NTBT
- Interleukin-11 [MeSH Descriptor]
- Interleukin-11 [MeSH concept]
- Interleukin-11 (substance) [SNOMED CT concept]
- interleukin-11 [SNOMED Notion]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Cytarabine/Daunorubicin/Interleukin-11/Sargramostim [NCIt concept]
- Filgrastim/Interleukin-11 [NCIt concept]
- Interleukin-11/Sargramostim [NCIt concept]

Keyword's position in hierarchy(ies) :

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