Esperamicin A1

Preferred Label : Esperamicin A1;

NCIt definition : An enediyne antineoplastic antibiotic hybrid containing an anthranilate moiety. Esperamicin A1 is isolated from the bacterium Actinomadura verrucosospora. The anthranilate component of esperamicin A1 intercalates DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-stranded breaks in DNA and apoptosis. (NCI04);

UNII : PLX8T21X8G;

CAS number : 99674-26-7;

NSC code : 372668;

ChEBI ID : CHEBI:53273;

Codes from synonyms : NSC0372668;

Details

Origin ID

C1301;

UMLS CUI

C0082481;

Currated CISMeF NLP mapping
- esperamicin A1 [MeSH concept]
- esperamicin A1 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- esperamicin A1 [MeSH concept]
- esperamicin A1 [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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