Preferred Label : Carbon C 11 Metformin;
NCIt synonyms : [11C]-metformin; Carbon-11 Metformin; 11C-metformin;
NCIt related terms : METFORMIN C-11;
NCIt definition : A radiopharmaceutical tracer containing the anti-diabetic agent metformin, a biguanide
and hydrophilic organic cation, and labeled with carbon 11 (11C), used to measure
metformin uptake by cancer cells using positron emission tomography (PET). Upon administration
of carbon C 11 metformin, the metformin moiety targets and binds to cancer cells;
in turn, the compound is taken up by cancer cells. Upon PET, metformin distribution
into cancer cells can be visualized, which allows for a prediction of the anti-cancer
efficacy of metformin, based on tumor cell uptake. Metformin transport, such as uptake
into cancer cells, appears to be correlated with the expression of organic cation
transporters (OCT) 1-3, multidrug and toxin extrusion (MATE) 1 and 2, and plasma membrane
monoamine transporter (PMAT). OCTs, MATEs and PMAT play a key role in the distribution
and excretion of organic cationic compounds.;
UNII : 6AI63CHT0T;
NCI Metathesaurus CUI : CL514004;
Origin ID : C130014;
UMLS CUI : C4329616;
Semantic type(s)
- concept_is_in_subset
