Preferred Label : Oxidative Phosphorylation Inhibitor IACS-010759;
NCIt synonyms : OXPHOS Inhibitor IACS-010759;
NCIt related terms : IACS-010759;
NCIt definition : An orally bioavailable oxidative phosphorylation (OxPhos) inhibitor, with potential
antineoplastic activity. Upon administration of the OxPhos inhibitor IACS-010759,
this agent binds to and inhibits complex I of the electron transport chain (NADH ubiquinone
oxidoreductase), thereby selectively depriving tumor cells of nutrients, and energy,
and inhibiting nucleotide and amino acid production, which induces autophagy, causes
tumor cell death and inhibits cell proliferation. Mitochondrial complex I, which is
hyperactivated in cancer cells to meet their increased demands for energy, plays a
key role in the promotion of cancer cell proliferation.;
UNII : 42W52V11DJ;
CAS number : 1570496-34-2;
Molecule name : IACS-010759;
NCI Metathesaurus CUI : CL513977;
Origin ID : C130012;
UMLS CUI : C4330908;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
