Preferred Label : Dolastatin 10;
NCIt synonyms : Dolastatin-10; L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-,
[2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]];
NCIt related terms : B720389K560;
NCIt definition : A pentapeptide originally isolated from the marine mollusk Dolabella auricularia with
potential antineoplastic activity. Binding to tubulin, Dolastatin 10 inhibits microtubule
assembly, resulting in the formation of tubulin aggregates and inhibition of mitosis.
This agent also induces tumor cell apoptosis through a mechanism involving bcl-2,
an oncoprotein that is overexpressed in some cancers. (NCI04);
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It binds to a protein
that cells need to divide and it may kill cancer cells. Dolastatin 10 comes from a
marine organism. It is a type of mitotic inhibitor.;
UNII : EI946JT51X;
CAS number : 110417-88-4;
Molecule name : B720389K560;
NSC code : 376128;
Codes from synonyms : NSC0376128; CDR0000045452;
Origin ID : C1300;
UMLS CUI : C0082338;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
