Preferred Label : Truncated Tissue Factor/NGR Peptide;
NCIt synonyms : tTF-NGR;
NCIt definition : A vascular-targeting agent composed of the extracellular domain of the trunctated
form of issue factor (tTF) conjugated to the C-terminal peptide GNGRAHA (NGR), with
potential procoagulatory and antineoplastic activities. Upon administration, the NGR
peptide moiety of tTF-NGR targets and binds to the surface protein aminopeptidase
N (CD13) expressed on endothelial cells in tumor vessels. Upon deamidation of the
NGR peptide moiety, this agent also binds to integrin alphaVbeta3 (aVb3; CD51/CD61)
in the tumor vasculature. In turn, the tTF causes occlusion of the tumor blood vessels,
which causes an inhibition of blood supply and flow in the tumor, nutrition and induced
tumor cell death and an inhibition of tumor cell proliferation. TF plays a key role
in the coagulation cascade. NGR is a asparagine-glycine-arginine containing peptide
and ligand of CD13. Both aVb3 and CD13 are surface proteins that are upregulated on
endothelial cells of tumor vessels.;
NCI Metathesaurus CUI : CL513383;
Origin ID : C129984;
UMLS CUI : C4331433;
Semantic type(s)
- concept_is_in_subset
