Myeloid/Lymphoid Neoplasms with JAK2 Rearrangement

Preferred Label : Myeloid/Lymphoid Neoplasms with JAK2 Rearrangement;

NCIt synonyms : Myeloid and Lymphoid Neoplasms with t(8;9)(p22;p24.1);PCM1-JAK2; Myeloid/Lymphoid Neoplasm with JAK2-PCM1 Fusion; Myeloid/Lymphoid Neoplasm with PCM1- JAK2 Fusion; Myeloid/Lymphoid Neoplasms with PCM1::JAK2; M/LN-eo with t(8;9)(p22;p24.1)/PCM1/JAK2; Myeloid/Lymphoid Neoplasms with PCM1-JAK2; M/LN-eo with t(8;9)(p22;p24.1)/PCM1::JAK2; Myeloid and Lymphoid Neoplasms with t(8;9)(p22;p24.1);PCM1::JAK2; Myeloid/Lymphoid Neoplasm with JAK2 Rearrangement;

NCIt definition : Hematologic neoplasms characterized by the presence of t(8;9)(p22;p24.1) that results in PCM1-JAK2 fusion gene expression. It is associated with eosinophilia, bone marrow findings of left-shifted erythroid predominance, lymphoid aggregates, and often myelofibrosis. Rare cases present as T- or B-acute lymphoblastic leukemia.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL512939;

Details

Origin ID

C129853;

UMLS CUI

C5229383;

Automatic exact mappings (from CISMeF team)
- Myeloid or lymphoid neoplasm with PCM1-JAK2 [ICD-11 Extension code]
- Myeloid-lymphoid neoplasm with JAK2 rearrangement (morphologic abnormality) [SNOMED CT concept]
- Myeloid/lymphoid neoplasm associated with JAK2 rearrangement [ORDO Disease]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- t(8;9)(p22;p24.1) [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Myeloid and/or lymphoid neoplasm with pericentriolar material 1-janus kinase 2 (disorder) [SNOMED CT concept]
- Myeloid-lymphoid neoplasm with JAK2 rearrangement (morphologic abnormality) [SNOMED CT concept]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
disease_excludes_molecular_abnormality
- BCR-ABL1 Fusion Protein Expression [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_finding
- Eosinophilia [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_molecular_abnormality
- JAK2 Gene Rearrangement [NCIt concept]
- Tyrosine Kinase Gene Fusion [NCIt concept]
disease_has_normal_cell_origin
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Pluripotent Stem Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- PCM1/JAK2 Fusion Gene [NCIt concept]
pathogenesis_of_disease_involves_gene
- PCM1/JAK2 Fusion Gene [NCIt concept]

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