Etelcalcetide - CISMeF

Preferred Label : Etelcalcetide;

NCIt synonyms : N-acetyl-D-cysteinyl-S-(L-cysteine disulfide)-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide; Velcalcetide;

NCIt definition : A calcimimetic and calcium-sensing receptor (CaSR) agonist composed of a synthetic peptide comprised of seven D-amino acids that can be used to treat secondary hyperparathyroidism (sHPT) in hemodialysis patients with chronic kidney disease (CKD). Upon intravenous administration, etelcalcetide mimics calcium and allosterically binds to and activates the CaSR expressed by the parathyroid gland. This suppresses the synthesis and secretion of parathyroid hormone (PTH), thereby reducing PTH levels and lowering serum calcium and phosphorus levels. Elevated PTH is often observed in patients with CKD and is associated with dysregulated calcium-phosphate homeostasis.;

UNII : 60ME133FJB;

InChIKey : ANIAZGVDEUQPRI-ZJQCGQFWSA-N;

CAS number : 1262780-97-1;

Drug name : Parsabiv;

Molecule name : AMG 416; AMG416; KAI 4169; KAI-4169;

Details

Origin ID

C129712;

UMLS CUI

C3713906;

Automatic exact mappings (from CISMeF team)
- velcalcetide [MeSH concept]
Currated CISMeF NLP mapping
- Etelcalcetide [ICD-11 Extension code]
- Etelcalcetide [SMS substance]
- Etelcalcetide (substance) [SNOMED CT concept]
- etelcalcetide [MeSH concept]
See also inter- (CISMeF)
- Parsabiv [MeSH concept]
- Product containing etelcalcetide (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hormone [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Etelcalcetide (substance) [SNOMED CT concept]
- Product containing etelcalcetide (medicinal product) [SNOMED CT concept]
- etelcalcetide [ATC Code]
- velcalcetide [MeSH concept]
Validated automatic mappings to BTNT
- etelcalcetide [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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