Preferred Label : Polysiloxane/Gadolinium Chelates-based Nanoparticles;
NCIt synonyms : AGuIX-NP; Gadolinium-Based Nanoparticle; Polysiloxane/Gadolinium-DOTA Chelates-based Nanoparticles; Polysiloxane Matrix-gadolinium Chelates-based Nanoparticles;
NCIt definition : A nanoparticle formulation composed of a polysiloxane-based inorganic matrix bound
to cyclic chelates composed of the chelating agent DOTA (1,4,7,10-tetra-azacyclododecane-1-glutaric
anhydride-4,7,10-triacetic acid) covalently bound to the paramagnetic contrast enhancer
gadolinium (Gd), a high-Z material, with potential use in enhancing diagnostic images
upon magnetic resonance imaging (MRI) and potential radiosensitizing activity. Upon
intravenous administration of polysiloxane matrix-gadolinium chelates-based nanoparticles,
the nanoparticles extravasate to tumor sites due to the unique, hyperpermeable environment
of the tumor vasculature. In addition, the small nanoparticles allow for deep penetration
into the tumor, where they subsequently accumulate. Upon placement in a magnetic field,
this agent produces a large magnetic moment and creates a large local magnetic field,
which can enhance the relaxation rate of nearby protons. This change in proton relaxation
dynamics increases the MRI signal intensity of tissues in which this agent has accumulated;
therefore, contrast and visualization of those tissues are enhanced compared to unenhanced
MRI. The ultra-small nanoparticles, less than 5 nm in diameter, allow for rapid renal
clearance and reduced toxicity. Due to their magnetic properties, these nanoparticles
make tumor cells more sensitive to radiation therapy.;
Drug name : AGuIX;
NCI Metathesaurus CUI : CL512625;
Origin ID : C129651;
UMLS CUI : C4331021;
Semantic type(s)
- concept_is_in_subset
