Preferred Label : CD4-specific Telomerase Peptide Vaccine UCPVax;
NCIt synonyms : UCP2/UCP4 CD4-specific Telomerase Peptide Vaccine UCPVax;
NCIt definition : A therapeutic peptide vaccine containing the human telomerase reverse transcriptase
catalytic subunit (hTERT)-derived universal cancer peptides 2 (UCP2) and 4 (UCP4),
and combined with the immunoadjuvant Montanide ISA 51 VG, with potential immunostimulating
and antineoplastic activities. Vaccination with the CD4-specific telomerase peptide
vaccine UCPVax activates the immune system to mount a T-helper 1 (TH1) CD4-positive
T-lymphocyte immune response against and ultimately killing telomerase-expressing
cells. Telomerase, a reverse transcriptase normally repressed in healthy cells, is
overexpressed in most cancer cells and plays a key role in cellular proliferation.;
Drug name : UCPVax;
NCI Metathesaurus CUI : CL512660;
Origin ID : C129596;
UMLS CUI : C4329512;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
