" /> Lirentelimab - CISMeF





Preferred Label : Lirentelimab;

NCIt synonyms : Monoclonal Antibody AK 002;

NCIt definition : A humanized, nonfucosylated immunoglobulin G1 (IgG1) monoclonal antibody directed against the inhibitory receptor sialic acid-binding immunoglobulin-like lectin 8 (Siglec-8) expressed on human mast cells and eosinophils, with potential anti-inflammatory activity. Upon administration, lirentelimab targets and binds to Siglec-8 expressed on the surface of mast cells and eosinophils. This may inhibit mast cell activation and deplete eosinophils through antibody-dependent cell-mediated cytotoxicity (ADCC) and apoptosis. This may reduce abnormal proliferation of mast cells and eosinophils, which plays a key role in allergic and inflammatory responses.;

UNII : SWS48LJU3T;

CAS number : 2283348-97-8;

Molecule name : AK 002; AK002;

NCI Metathesaurus CUI : CL512560;

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28/07/2025


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