Preferred Label : Fluorescent Dye LS301;
NCIt synonyms : NIR Fluorescent Probe LS301; Cypate-cyclo (D-Cys-Gly-Arg--Asp-Ser-Pro-Cys)-Lys-OH;
NCIt related terms : LS-301;
NCIt definition : A hydrophobic near-infrared (NIR) fluorescent probe composed of a NIR fluorescent
dye cypate linked to an unnatural D-cysteine-containing cyclic octapeptide (D-Cys-Gly-Arg--Asp-Ser-Pro-Cys)-Lys-OH,
with potential cancer imaging activity. Upon administration during tumor resection,
the peptide component of LS301 specifically targets and binds integrin receptors expressed
on tumor cells, which are not expressed on normal, healthy cells. Upon receptor-mediated
endocytosis and fluorescence imaging using infrared light that is visualized by the
surgeon with special Cancer Vision Goggles (CVG), tumor cells can be detected, identified,
and removed accordingly. This enhances the accuracy of cancer cell removal during
surgery. The D-cysteine on the peptide prevents degradation by endogenous proteases.;
UNII : M48HCF27ZE;
CAS number : 2041574-23-4;
Molecule name : LS-301; LS 301;
NCI Metathesaurus CUI : CL512635;
Origin ID : C129590;
UMLS CUI : C4329994;
Semantic type(s)
- concept_is_in_subset
- has_target
