Preferred Label : Zinc Finger Nuclease ZFN-758;
NCIt synonyms : ZFN ZFN-758;
NCIt definition : A zinc finger nuclease (ZFN) targeting the human papillomavirus (HPV) type 18 (HPV18)
oncoprotein E7, with potential antineoplastic activity. Upon transfection of ZFN-758
into HPV18-positive cells, ZFN-758 targets, binds to and cleaves the HPV18 E7 oncogene
in HPV18-infected cells. By cleaving the HPV18 E7 DNA, the E7 oncoprotein is not expressed.
This results in an inhibition of E7-mediated signaling, an induction of apoptosis,
and an inhibition of tumor cell proliferation in HPV18-expressing cells. In addition,
preventing E7 expression induces the expression of tumor suppressor genes, thereby
further preventing HPV-induced cancer cell formation and proliferation. E7 plays a
key role in promoting both viral infection and carcinogenesis. ZFN, an engineered
endonuclease in which a DNA-binding zinc finger protein is fused to a DNA-cleavable
domain, cleaves specific DNA sites.;
Molecule name : ZFN-758;
NCI Metathesaurus CUI : CL512594;
Origin ID : C129589;
UMLS CUI : C4331799;
Semantic type(s)
- concept_is_in_subset
