Preferred Label : Zinc Finger Nuclease ZFN-603;
NCIt synonyms : ZFN ZFN-603;
NCIt definition : A zinc finger nuclease (ZFN) targeting the human papillomavirus (HPV) type 16 (HPV16)
oncoprotein E7, with potential antineoplastic activity. Upon transfection of ZFN-603
into HPV16-positive cells, ZFN-603 targets, binds to and cleaves the HPV16 E7 oncogene
in HPV16-infected cells. By cleaving the HPV16 E7 DNA, the E7 oncoprotein is not expressed.
This results in an inhibition of E7-mediated signaling, an induction of apoptosis,
and inhibition of tumor cell proliferation in HPV16-expressing cells. In addition,
preventing E7 expression induces the expression of tumor suppressor genes, thereby
further preventing HPV-induced cancer cell formation and proliferation. E7 plays a
key role in promoting both viral infection and carcinogenesis. ZFN, an engineered
endonuclease in which a DNA-binding zinc finger protein is fused to a DNA-cleavable
domain, cleaves specific DNA sites.;
Molecule name : ZFN-603;
NCI Metathesaurus CUI : CL512593;
Origin ID : C129588;
UMLS CUI : C4331798;
Semantic type(s)
- concept_is_in_subset
