Plasmin-Antiplasmin Complex

Preferred Label : Plasmin-Antiplasmin Complex;

NCIt synonyms : Plasmin/Alpha-2-Antiplasmin Complex; PAP; Plasmin/Antiplasmin Complex;

NCIt definition : A protein complex comprised of the serine proteinase plasmin irreversibly bound to its corresponding serine proteinase inhibitor protein (SERPIN) alpha-2-antiplasmin.;

NCIt note : The plasmin-antiplasmin complex is usually efficiently cleared from the blood by the liver before the complex can dissociate. However, the presence of elevated concentrations of this complex may permit the regeneration of inactive alpha-2-antiplasmin and free active plasmin. This may lead to aberrant activation of fibrinolysis, complement cascades or collagenases. Therefore, elevated blood concentration of this complex is associated with vascular and/or inflammatory diseases, such as disseminated intravascular coagulation and rheumatic disorders.;

Details

Origin ID

C129410;

UMLS CUI

C0760170;

Automatic exact mappings (from CISMeF team)
- Development- and differentiation-enhancing factor 2 [OMIM gene]
- GLI family zinc finger 3 [ORDO Gene]
- Pdgfa-associated protein 1 [OMIM gene]
- Phosphatase, prostate-specific acid [OMIM gene]
- Pituitary adenoma 1, multiple types [OMIM Phenotype]
- Poly(a) polymerase, alpha [OMIM gene]
- Regenerating islet-derived 3-alpha [OMIM gene]
- polyphosphate:AMP phosphotransferase activity [GO term]
- pulmonary alveolar proteinosis [MeSH Descriptor]
- pulmonary wedge pressure [MeSH Descriptor]
Currated CISMeF NLP mapping
- Plasmin-plasmin inhibitor complex [LOINC component]
- plasmin-plasmin inhibitor complex [MeSH Supplementary Concept]
- plasmin-plasmin inhibitor complex [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- alpha 2-plasmin inhibitor-plasmin complex [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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