Preferred Label : Antibody-drug Conjugate Anti-TIM-1-vcMMAE CDX-014;
NCIt synonyms : CR014-vcMMAE; CR014-vc-MMAE; ADC CDX-014; Antibody-drug Conjugate CDX-014; ADC Anti-TIM-1-vcMMAE CDX-014;
NCIt related terms : CDX-014;
NCIt definition : A monoclonal antibody-drug conjugate (ADC) comprised of human immunoglobulin G1 (IgG1)
clone CR014, which targets the extracellular domain of T-cell immunoglobulin mucin-1
(TIM-1; HAVCR1), that is linked, via a valine-citrulline (VC) peptide linker, to the
potent cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic
activity. Upon administration of ADC anti-TIM-1-vcMMAE CDX-014, the monoclonal antibody
moiety targets and binds to TIM-1. Upon internalization and proteolytic cleavage,
MMAE is released into the cytosol of TIM-1-expressing tumor cells, binds to tubulin,
and inhibits microtubule polymerization, which induces both G2/M phase arrest and
tumor cell apoptosis. TIM-1 is upregulated in a variety of cancer cell types while
only minimally expressed in healthy tissue. The linkage system in CDX-014 is highly
stable in plasma, resulting in increased specificity and cytotoxic efficacy towards
TIM-1-positive cells.;
UNII : GJV1PP34M2;
Molecule name : CDX-014;
NCI Metathesaurus CUI : CL512670;
Origin ID : C129401;
UMLS CUI : C4329346;
Semantic type(s)
- concept_is_in_subset
- has_target
