Preferred Label : Hydrogen Peroxide-hyaluronic Acid Tumor Injectable Formulation;
NCIt synonyms : H2O2-HA Tumor Injectable Formulation; Hydrogen Peroxide-hyaluronic Acid Intratumoral Injectable Formulation;
NCIt definition : A gel-based formulation composed of a very dilute solution of hydrogen peroxide (H2O2)
combined with hyaluronic acid (HA), with potential radiosensitizing activity. Upon
intratumoral injection and slow-release (SR) of H2O2 from the gel, H2O2 releases oxygen
and inactivates anti-oxidative enzymes, thereby increasing the oxygen concentration
in the tumor environment, which increases the efficacy of radiotherapeutic treatment.
HA increases viscosity of the formulation and allows for the SR of H2O2; as compared
to the injection of H2O2 alone, the addition of HA decreases diffusion of H2O2 to
surrounding areas and enhances intratumoral H2O2 concentration over an increased period
of time. Hypoxic tumors show a decreased response to radiotherapy; thus, increasing
oxygen content increases tumor response to radiotherapy.;
NCI Metathesaurus CUI : CL512558;
Origin ID : C129385;
UMLS CUI : C4330336;
Semantic type(s)
- concept_is_in_subset
