Preferred Label : Simlukafusp Alfa;
NCIt synonyms : FAP-IL2v RO6874281; aFAP-IL2v RO6874281; FAP-IL2v FP RO6874281; Anti-FAP/Interleukin-2 Fusion Protein RO6874281;
NCIt definition : A recombinant fusion protein comprised of a human monoclonal antibody directed against
fibroblast activation protein-alpha (FAP) linked to an engineered, variant form of
interleukin-2 (IL-2v), with potential immunostimulating and antineoplastic activities.
Upon administration of simlukafusp alfa, the monoclonal antibody moiety recognizes
and binds to FAP, thereby concentrating IL-2 in FAP-expressing tumor tissue. Subsequently,
the IL-2 moiety of this fusion protein may stimulate a local immune response and activate
natural killer (NK) cells and cytotoxic T-cells. FAP is a cell surface protein that
is expressed on a wide variety of cancer cells. IL-2v cannot bind to IL-2 receptor-alpha
(CD25, IL2Ra) and does not activate regulatory T-cells (Tregs).;
UNII : FL08SGO9XA;
CAS number : 1776942-10-9;
Molecule name : RG 7461; RO 6874281; RO-6874281; RG-7461;
NCI Metathesaurus CUI : CL512652;
Origin ID : C129383;
UMLS CUI : C5432346;
Semantic type(s)
- concept_is_in_subset
- has_target
