Ribozyme - CISMeF

Preferred Label : Ribozyme;

NCIt synonyms : RNA, Catalytic;

NCIt related terms : Catalytic RNA; Ribonucleic Enzyme;

NCIt definition : RNA that contains an intron sequence which has an enzyme-like catalytic activity. This intron sequence has been shown to fold up to form a complex surface that can function like an enzyme in reactions with other RNA molecules and thus synthesize new molecules even in the absence of protein. Synthetic ribozymes can be engineered to specifically cleave a target RNA sequence causing expression down regulation.;

Alternative definition : CDISC: RNA that contains an intron sequence which has an enzyme-like catalytic activity. This intron sequence can function like an enzyme in reactions with other RNA molecules and thus synthesize new molecules even in the absence of protein.;

Details

Origin ID

C1292;

UMLS CUI

C0080125;

Currated CISMeF NLP mapping
- RNA, catalytic [MeSH concept]
- obsolete ribozyme [GO term]
- rna, catalytic [MeSH Descriptor]
Semantic type(s)
- Enzyme [UMLS semantic type]
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
UMLS correspondences (same concept)
- RNA, catalytic [MeSH concept]
- rna, catalytic [MeSH Descriptor]
concept_is_in_subset
- CDISC SDTM Genetic Sample Type Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_product_has_biochemical_function
- Enzyme [NCIt concept]

Keyword's position in hierarchy(ies) :

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