Preferred Label : Doxorubicin-loaded EGFR-targeting Nanocells;
NCIt synonyms : EGFR-targeted EnGeneIC Dream Vectors Containing Doxorubicin; EGFR (Vectibix Sequence)-Targeted EnGeneIC Dream Vectors Containing Doxorubicin; EGFR(V)-EDV-Dox; Doxorubicin-loaded EGFR-targeting Nanocell;
NCIt definition : A nanocell formulation targeting the epidermal growth factor receptor (EGFR) using
bispecific antibodies (bsAb) against EGFR and containing the antineoplastic anthracycline
antibiotic doxorubicin, with potential antineoplastic activity. Upon administration
of doxorubicin-loaded EGFR-targeting nanocells, the nanocells are stable in the bloodstream
and the anti-EGFR bsAb moiety targets and binds to EGFR-expressing tumor cells. Upon
binding, the nanocell allows for specific delivery of doxorubicin to tumor cells overexpressing
EGFR. Upon endocytosis by the tumor cells, the nanocell is broken down and releases
doxorubicin, which intercalates into DNA and interferes with topoisomerase II activity,
thereby inhibiting DNA replication and RNA synthesis. Compared to doxorubicin alone
or liposomal doxorubicin, targeted delivery of doxorubicin improves efficacy while
lowering the toxicity profile. EGFR, a tyrosine kinase receptor, is overexpressed
in many cancer cell types. The nanocell is a bacterially derived nanosphere; the bacterial
components are unlikely to induce an immune response in the immunosuppressed tumor
microenvironment.;
NCI Metathesaurus CUI : CL512145;
Origin ID : C128897;
UMLS CUI : C4289669;
Semantic type(s)
- concept_is_in_subset
- has_target
