Preferred Label : 4SCAR-GD2-modified T-lymphocytes;
NCIt synonyms : GD2-specific 4th Generation Chimeric Antigen Receptor-modified T Cells; 4S-GD2-CAR-T-cells; 4SCAR-GD2; 4SCAR-GD2-modified T Cells; 4SCAR-GD2 T Cells;
NCIt definition : Genetically modified autologous T-lymphocytes transduced with a lentiviral vector
encoding a fourth generation specific chimeric antigen receptor (4SCAR) specific for
the disialoganglioside GD2 and which includes the CD3zeta chain and the signaling
domains of the co-stimulatory molecules CD28, CD137, and CD27 fused with the suicide
gene inducible caspase 9 (iCasp9), with potential immunomodulating and antineoplastic
activities. Upon intravenous administration of 4SCAR-GD2 T-cells, these cells target
the GD2 antigen on tumor cells to induce selective toxicity against GD2-expressing
tumor cells. The tumor-associated antigen (TAA) GD2 is overexpressed on the surface
of neuroblastoma cells and by other neuroectoderm-derived neoplasms, while it is minimally
expressed on normal cells. iCasp9 consists of a human FK506 drug-binding domain with
an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells
lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered;
this binds to the drug binding FKBP12-F36V domain and activates caspase 9, which results
in the apoptosis of the administered T-cells and enhances safety of this agent. CD28,
CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for
full T-cell activation.;
NCI Metathesaurus CUI : CL512280;
Origin ID : C128896;
UMLS CUI : C4290030;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
