FGFR4 Inhibitor H3B-6527

Preferred Label : FGFR4 Inhibitor H3B-6527;

NCIt synonyms : Fibroblast Growth Factor Receptor 4 Inhibitor H3B-6527;

NCIt related terms : H3B-6527;

NCIt definition : An orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, H3B-6527 specifically binds to and blocks FGFR4. This prevents the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells. FGFR4, a receptor tyrosine kinase overexpressed by certain tumor cell types, is involved in tumor cell proliferation, differentiation, angiogenesis, and survival; FGFR4 expression is associated with poor prognosis.;

UNII : 4HTE364XIK;

CAS number : 1702259-66-2;

Molecule name : H3B-6527; H3B 6527;

NCI Metathesaurus CUI : CL512384;

Details

Origin ID

C128862;

UMLS CUI

C4287756;

Currated CISMeF NLP mapping
- H3B-6527 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- H3B-6527 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Fibroblast Growth Factor Receptor 4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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