Preferred Label : GAIA Level 1 First Trimester Spontaneous Abortion;
NCIt synonyms : Global Alignment of Immunization safety Assessment in pregnancy Level 1 First Trimester
Spontaneous Abortion;
NCIt related terms : Level 1 First Trimester Spontaneous Abortion;
NCIt definition : GAIA Level 1 First Trimester Spontaneous Abortion is defined by two criteria: first,
at least one of the following three requirements must be met: a) Crown-rump length
greater than or equal to 7 mm and no visible heartbeat on transvaginal ultrasound;
OR b) Crown-rump length greater than or equal to 15 mm and no visible heartbeat on
abdominal ultrasound; OR c) Ultrasound examination demonstrating mean gestational
sac diameter greater than or equal to 25 mm and no visible embryo or yolk sac; second,
at least one of the following three requirements must be met: a) A second transvaginal
ultrasound performed greater than or equal to 7 days later (or 14 days later if transabdominal)
confirming the diagnosis of a non-viable pregnancy; OR b) The absence of an embryo
with heartbeat 2 weeks or more after a transabdominal scan that initially showed a
gestational sac without a yolk sac; OR c) The absence of an embryo with a heartbeat
11 days or more after a transvaginal scan that initially showed a gestational sac
with a yolk sac. Alternatively, GAIA Level 1 First Trimester Spontaneous Abortion
can be defined by the following two criteria: first, the gestational age is within
the pre-defined range for the selected abortion definition as assessed by maternal
and/or fetal parameters ( Level 1-2) (using the Brighton Preterm Birth Gestational
Age algorithm); second, at least one of the following four requirements must be met:
a) Positive urine or blood pregnancy test that becomes negative after 7 days; OR b)
Products of conception found on histopathological evaluation of pregnancy tissue;
OR c) Ultrasound examination demonstrating an empty uterine cavity in a woman who
had clear evidence of intrauterine pregnancy on previous ultrasound examination; OR
d) Vaginal bleeding, external cervical os open or closed, with visible expulsion of
pregnancy tissues/products of conception.;
Alternative definition : GAIA: Level 1 First Trimester Spontaneous Abortion is defined by two criteria: first,
at least one of the following three requirements must be met: a) Crown-rump length
greater than or equal to 7 mm and no visible heartbeat on transvaginal ultrasound;
OR b) Crown-rump length greater than or equal to 15 mm and no visible heartbeat on
abdominal ultrasound; OR c) Ultrasound examination demonstrating mean gestational
sac diameter greater than or equal to 25 mm and no visible embryo or yolk sac; second,
at least one of the following three requirements must be met: a) A second transvaginal
ultrasound performed greater than or equal to 7 days later (or 14 days later if transabdominal)
confirming the diagnosis of a non-viable pregnancy; OR b) The absence of an embryo
with heartbeat 2 weeks or more after a transabdominal scan that initially showed a
gestational sac without a yolk sac; OR c) The absence of an embryo with a heartbeat
11 days or more after a transvaginal scan that initially showed a gestational sac
with a yolk sac. Alternatively, Level 1 First Trimester Spontaneous Abortion can be
defined by the following two criteria: first, the gestational age is within the pre-defined
range for the selected abortion definition as assessed by maternal and/or fetal parameters
( Level 1-2) (using the Brighton Preterm Birth Gestational Age algorithm); second,
at least one of the following four requirements must be met: a) Positive urine or
blood pregnancy test that becomes negative after 7 days; OR b) Products of conception
found on histopathological evaluation of pregnancy tissue; OR c) Ultrasound examination
demonstrating an empty uterine cavity in a woman who had clear evidence of intrauterine
pregnancy on previous ultrasound examination; OR d) Vaginal bleeding, external cervical
os open or closed, with visible expulsion of pregnancy tissues/products of conception.;
NCI Metathesaurus CUI : CL509079;
Origin ID : C128776;
UMLS CUI : C4289217;
Semantic type(s)
- concept_is_in_subset
