NCIt definition : A humanized monoclonal antibody fragment directed against the thrombin-binding site
of dabigatran, that may be used as a specific reversal agent for dabigatran. Upon
intravenous administration, idarucizumab binds to dabigatran and its acylglucuronide
metabolites with a higher affinity than the binding affinity of dabigatran to thrombin,
thereby neutralizing the anticoagulant effect of dabigatran.;