NCIt definition : A rare disease caused by the human papillomavirus (HPV), most commonly types 6 and
11, that affects tissue along the respiratory tract with the majority of cases affecting
the larynx. The disease has a bimodal distribution and manifests in those younger
than age 5, juvenile-onset recurrent respiratory papillomatosis (JORRP), and those
older than age 40, adult-onset recurrent respiratory papillomatosis (AORRP). JORRP
is more common and more severe in presentation than AORRP. In a small percentage of
patients, respiratory papillomas may undergo malignant transformation to squamous
cell carcinomas that have a poor prognosis.;