Preferred Label : TLR4 Agonist GSK1795091;
NCIt synonyms : TLR 4 Agonist GSK1795091; Toll-like Receptor 4 Agonist GSK1795091;
NCIt related terms : GSK-1795091;
NCIt definition : A toll-like receptor 4 (TLR4) agonist, with potential immunoadjuvant activity. Upon
administration, GSK1795091 binds to and activates TLR4, thereby stimulating dendritic
cells (DCs), monocytes and macrophages. This activation results in the production
of pro-inflammatory cytokines, including interferon gamma (IFN-g), tumor necrosis
factor-alpha (TNF-a) and the interleukins (IL), IL-1 beta, -6 and -12. This may induce
a T helper cell-1 (Th1) immune response and, upon co-administration of a vaccine containing
tumor-associated antigens (TAAs), activates a cytotoxic T-lymphocyte (CTL) response
against tumor cells expressing those TAAs. TLR4, a member of the TLR family, plays
a key role in the activation of innate immunity.;
UNII : 5D8VHL5WH5;
CAS number : 1233589-81-5;
Molecule name : GSK1795091;
NCI Metathesaurus CUI : CL507944;
Origin ID : C128558;
UMLS CUI : C4287760;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
