Preferred Label : Perflubutane Microbubble;
NCIt synonyms : Perflubutane Microsphere; PFB Microbubble; Microbubble Ultrasound Contrast Agent PFB;
NCIt definition : A phospholipid-stabilized suspension composed of microbubbles containing the gas perfluorobutane
(perflubutane, PFB) with an outer layer of hydrogenated egg phosphatidylserine (HEPS),
which can be used as an ultrasound imaging contrast agent. Upon administration, the
PFB microbubbles enhance echo differences between various tissues, which enhances
the visualization of images during ultrasound. In particular, the PFB microbubbles
seem to preferentially target the reticuloendothelial system (RES); they are taken
up by macrophages in the spleen and liver (Kupffer cells), and are taken up in lymph
nodes. This may aid in the detection and diagnosis of cancer and liver disease, and
may improve imaging of the lymphatic and vascular systems. The microbubbles provide
increased stability during ultrasound imaging.;
Drug name : Sonazoid;
Origin ID : C128488;
UMLS CUI : C4288410;
Semantic type(s)
- concept_is_in_subset
