Preferred Label : HPV-16 E7 TCR Expressing T-cells;
NCIt synonyms : Human Papillomavirus Type 16 E7 TCR Expressing T-cells; HPV-16 E7 TCR-expressing T Lymphocytes; HPV-16 E7 TCR Expressing T-lymphocytes;
NCIt definition : A preparation of allogeneic, genetically engineered T-lymphocytes transduced with
a retroviral vector MSGV1 that encodes a T-cell receptor (TCR) targeting a specific
epitope of the human papillomavirus (HPV) type 16 oncoprotein E7 (HPV-16 E7 TCR),
with potential antineoplastic activity. The TCR especially recognizes and binds with
high affinity to the HPV 16 E7 11-19 epitope. Upon administration, HPV-16 E7 expressing
T-cells target and bind to tumor cells expressing the HPV-16 E7 antigen leading to
selective cytotoxicity in HLA-A2-positive, HPV-16 E7-expressing tumor cells. HPV16
E7, a tumor-associated antigen (TAA), overexpressed in a variety of tumor cell types
while not expressed in normal, healthy cells, plays a key role in tumor cell proliferation.
E7 11-19 is a naturally processed epitope of HPV-16 E7 that binds specifically to
human leukocyte antigen (HLA)-A*02:01 and that has been isolated from the surface
of HPV-16 positive, HLA-A*02:01-positive tumor cells.;
NCI Metathesaurus CUI : CL509618;
Origin ID : C128485;
UMLS CUI : C4289001;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
