" /> Megakaryocyte-Potentiating Factor - CISMeF





Preferred Label : Megakaryocyte-Potentiating Factor;

NCIt synonyms : Soluble Mesothelin Related Protein; SMR; SMRP; Megakaryocyte Potentiating Factor; OV569 Antigen; MPF; Soluble MPF/Mesothelin-Related Protein; Soluble MPF Mesothelin Related Protein; Soluble Mesothelin/MPF-Related Protein; Soluble MPF/Mesothelin Related Protein;

NCIt definition : Megakaryocyte-potentiating factor (250 aa, 27 kDa) is encoded by the human MSLN gene. This protein plays a role in megakaryocyte colony formation.;

NCIt note : An antibody that reacts with ovarian cancers and mesotheliomas was used to isolate a cell surface antigen named mesothelin. Although the function of mesothelin is unknown, it may play a role in cellular adhesion and is present on mesothelium, mesotheliomas, and ovarian cancers. Three transcript variants have been described for this gene and their protein products were initially named megakaryocyte potentiating factor (MPF), mesothelin, and the soluble member(s) of the mesothelin/MPF family. The protein isoform named MPF is a cytokine with megakaryocyte potentiating activity. The soluble member encoded by the third splice variant is detected in ovarian carcinoma; the full length sequence of the third variant has not been described. (LocusLink);

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16/05/2024


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