Preferred Label : Broccoli Sprout/Broccoli Seed Extract Supplement;
NCIt definition : A tablet-based nutritional supplement composed of a mixture of sprout and seed extracts
of the cruciferous vegetable broccoli, with potential chemopreventive and antioxidant
activities. Broccoli sprout/broccoli seed extract contains a high amount of both the
glycosinolate glucoraphanin and the enzyme myrosinase, which catalyzes the production
of glucoraphanin to sulforaphane. Upon administration of the broccoli sprout/broccoli
seed extract, sulforaphane activates the transcription factor NF-E2-related factor
2 (Nrf2), a member of the basic leucine zipper family, which binds to and activates
antioxidant-response elements (AREs). Subsequently, activated AREs promote the transcription
of antioxidant and detoxifying enzymes, particularly glutathione-S-transferase and
NAD(P)H dehydrogenase [quinone] 1 (NAD(P)H:quinone oxidoreductase; NQO1), resulting
in the detoxification of highly reactive carcinogens. This accelerates the elimination
of carcinogens, may protect against cellular damage, and prevents cancer formation.
AREs are cis-acting regulatory enhancer elements found in the 5' flanking region of
many phase II detoxification enzymes.;
Drug name : Avmacol;
NCI Metathesaurus CUI : CL507940;
Origin ID : C128293;
UMLS CUI : C4289906;
Semantic type(s)
- Food [UMLS semantic type]
- concept_is_in_subset
