Preferred Label : Nemvaleukin Alfa;
NCIt synonyms : Intermediate-affinity IL-2R Agonist ALKS 4230; Intermediate-affinity Interleukin-2 Receptor Agonist ALKS 4230;
NCIt definition : A selective effector cell activator protein and agonist of the intermediate-affinity
interleukin-2 (IL-2) receptor with potential immunostimulating and antineoplastic
activity. Upon administration, nemvaleukin alfa binds to and signals through the intermediate-affinity
IL-2 receptor complex; this may selectively stimulate and activate natural killer
(NK) cells and memory CD8 T-cells, leading to tumor cell elimination, while circumventing
the activation of immunosuppressive cells that may prevent the anti-tumor response.
IL-2 is a cytokine signaling molecule that plays a critical role in the immune response.;
UNII : 7ZX1Q9SJ1F;
CAS number : 2315268-27-8;
Molecule name : ALKS 4230; RDB 1450; RDB-1450;
NCI Metathesaurus CUI : CL507938;
Origin ID : C128107;
UMLS CUI : C5446304;
Semantic type(s)
- concept_is_in_subset
