Preferred Label : Gallium Ga 68-NOTA-BBN(7-14)-RGD;
NCIt synonyms : Gallium Ga 68-NOTA-BBN-RGD; 68Ga-NOTA-BBN-RGD; 68Ga-NOTA-BBN(7-14)-RGD;
NCIt definition : A radioconjugate containing the bombesin (BBN) fragment BBN(7-14) comprised of the
amino acid sequence Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2, which targets the gastrin-releasing
peptide receptor (GRPR), and linked, via a glutamate linker, to the cyclic arginine-glycine-aspartic
acid (RGD) sequence-based peptide cyclo[Arg-Gly-Asp-D-Tyr-Lys] (c(RGDyK)), which targets
integrin alphaVbeta3 (aVb3), and labeled with the radionuclide gallium (Ga) 68 through
the macrocyclic chelating agent, 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA),
with potential use in diagnostic imaging using positron emission tomography/computed
tomography (PET/CT). Upon administration of gallium Ga 68-NOTA-BBN(7-14)-RGD, the
BBN peptide moiety of the RGD-BBN heterodimer specifically targets and binds to GRPR
while the RGD moiety specifically binds to the aVb3. Upon PET/CT, GRPR- and/or aVb3-expressing
tumor cells can be visualized and expression levels can be quantified. GRPR, also
called bombesin receptor 2 (BB2), is a seven-transmembrane G protein-coupled receptor
belonging to the bombesin receptor family. aVb3, an integrin receptor, plays a key
role in angiogenesis, tumor proliferation and survival. Both are overexpressed in
certain types of cancers.;
NCI Metathesaurus CUI : CL507928;
Origin ID : C128035;
UMLS CUI : C4289046;
Semantic type(s)
- concept_is_in_subset
