Preferred Label : GAIA Level 1 Assessment of Premature Preterm Rupture of Membranes;
NCIt synonyms : Global Alignment of Immunization safety Assessment in pregnancy Level 1 Assessment
of Premature Preterm Rupture of Membranes;
NCIt related terms : Level 1 Assessment of Premature Preterm Rupture of Membranes;
NCIt definition : GAIA Level 1 Assessment of Premature Preterm Rupture of Membranes is defined by five
criteria: first, presentation between 24 0/7 and 36 6/7 weeks gestation with a clinical
history of rupture of membranes, the fluid from which may be any color, including
clear, blood-tinged, meconium-tinged (fetal stool), or purulent-tinged (yellowish,
suggesting infection); second, the patient is determined to not be in preterm labor
(having less than or equal to 4 contractions per hour documented clinically or on
tocodynometer, with less than 2cm cervical dilation); third, visible leakage of fluid
on vaginal speculum exam; fourth, one of the two following requirements must be met:
a) Visible arborization (ferning) on microscopy of amniotic fluid; OR b) Ultrasound
with oligohydramnios (amniotic fluid index (AFI) less than 5, or maximum vertical
pocket (MVP) less than 2); fifth, documentation of the membrane rupture by one of
the following diagnostic tests: a) Positive intra-amniotic dye-injection method; b)
Positive result on amniotic fluid alpha-fetoprotein test kit; c) Amniotic fluid pH
measurement (nitrazine paper test); d) Amniotic fluid placental alpha macroglobulin-1
protein assay (PAMG-1) test (AmniSure test); e) Amniotic fluid insulin-like growth
factor binding protein (IGFBP-1) test (Actim PROM test).;
Alternative definition : GAIA: Level 1 Assessment of Premature Preterm Rupture of Membranes is defined by five
criteria: first, presentation between 24 0/7 and 36 6/7 weeks gestation with a clinical
history of rupture of membranes, the fluid from which may be any colour, including
clear, blood-tinged, meconium-tinged (fetal stool), or purulent-tinged (yellowish,
suggesting infection); second, the patient is determined to not be in preterm labor
(having less than or equal to 4 contractions per hour documented clinically or on
tocodynometer, with less than 2cm cervical dilation); third, visible leakage of fluid
on vaginal speculum exam; fourth, one of the two following requirements must be met:
a) Visible arborization (ferning) on microscopy of amniotic fluid; OR b) Ultrasound
with oligohydramnios (amniotic fluid index (AFI) less than 5, or maximum vertical
pocket (MVP) less than 2); fifth, documentation of the membrane rupture by one of
the following diagnostic tests: a) Positive intra-amniotic dye-injection method; b)
Positive result on amniotic fluid alpha-fetoprotein test kit; c) Amniotic fluid pH
measurement (nitrazine paper test); d) Amniotic fluid placental alpha macroglobulin-1
protein assay (PAMG-1) test (AmniSure test); e) Amniotic fluid insulin-like growth
factor binding protein (IGFBP-1) test (Actim PROM test).;
NCI Metathesaurus CUI : CL509147;
Origin ID : C127944;
UMLS CUI : C4289225;
Semantic type(s)
- concept_is_in_subset
