Preferred Label : NK Cell-enriched Donor Lymphocytes;
NCIt synonyms : NK Cell-enriched Allogeneic Lymphocytes;
NCIt definition : A preparation of donor-derived lymphocytes that are enriched for donor-derived natural
killer (NK) cells, with direct tumor cytotoxic activity. Following allogeneic stem
cell transplantation and subsequent infusion of the NK cell-enriched donor lymphocytes,
these cells recognize and bind to tumor cells, upon which they secrete and release
perforins, granzymes, and cytokines, which results in cancer cell lysis. Infusion
of donor lymphocytes is limited by the risk of graft-versus-host disease (GVHD) and
NK cells normally constitute only a small portion of circulating lymphocytes. Therefore,
NK cell-enrichment may result in higher amounts of NK cells per infusion and improved
anti-tumor immunity without increasing the risk of GVHD.;
NCI Metathesaurus CUI : CL509285;
Origin ID : C127939;
UMLS CUI : C4288626;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
