Preferred Label : Bevifimod;
NCIt synonyms : SpA PRTX-100; Highly Purified Staphylococcal Protein A PRTX-100;
NCIt definition : A proprietary formulation containing a highly purified form of Staphylococcal protein
A (SpA; protein A), with potential immunomodulating activity. Upon administration
of bevifimod, this protein is able to specifically bind to both the subset of B-lymphocytes
that express the heavy chain variable region 3 (VH3)-encoded immunoglobulin (Ig) (VH3-B-cells)
and macrophages. This prevents B-cell activation, induces apoptosis, prevents VH3-derived
antibody formation, antibody-mediated immune responses, and destruction by macrophages.
This may modulate specific immune signaling pathways and restore normal immune system
functions caused by certain immune-mediated inflammatory diseases. In patients with
the autoimmune-mediated disease immune thrombocytopenia (ITP), PRTX-100 prevents destruction
of platelets, increases platelet production and platelet blood levels, and decreases
the risk of bleeding. SpA, a 42 kDa bacterial membrane protein produced by Staphylococcus
aureus bacteria, consists of five nearly identical Ig binding domains; each SpA domain
binds with high affinity to the Igs containing regions encoded by the VH3 gene family.
B-lymphocytes that express VH3-encoded Igs are specifically involved in various auto-immune
diseases.;
UNII : PNV0H3A73B;
CAS number : 2223113-32-2;
Molecule name : PRTX-100;
NCI Metathesaurus CUI : CL507917;
Origin ID : C127839;
UMLS CUI : C5139674;
Semantic type(s)
- concept_is_in_subset
