Preferred Label : DNA Repair Capacity;
NCIt definition : A cellular metabolic marker that may indicate an increased risk for neoplastic disease
that is based on a semi-quantitative determination of the ability of cells in a biological
sample to maintain the integrity of its genome.;
NCIt note : One method to determine DNA repair capacity involves incubating a sample with benzo[a]pyrene
diol epoxide (BPDE) for a few hours. After washing off the unbound BPDE, the amount
of BPDE-DNA adducts formed can be determined by the detection of the fluorescence
emitted by a fluorescently-labeled antibody that specifically binds to BPDE-DNA adducts.
Increased fluorescence is an indication of decreased DNA repair capacity. (J Natl
Cancer Inst. 2005; 97: 127-132. doi: 10.1093/jnci/dji013);
NCI Metathesaurus CUI : CL509433;
Origin ID : C127142;
UMLS CUI : C4289710;
Semantic type(s)
- concept_is_in_subset
