NCIt synonyms : Immunoglobulin G1, Anti-(Human Protein Vista (v-domain Immunoglobulin Suppressor of
T Cell Activation)) (Human Clone JNJ 61610588 gamma1-chain), Disulfide with Human
Clone JNJ; WHO 10758;
NCIt definition : A human monoclonal antibody against the protein V-domain immunoglobulin (Ig) suppressor
of T-cell activation (VISTA; programmed death 1 homolog; PD1H; PD-1H), with potential
negative checkpoint regulatory and antineoplastic activities. Upon administration,
onvatilimab targets and binds to VISTA. This inhibits VISTA signaling, abrogates the
VISTA-induced suppression of T-lymphocyte-mediated immune responses, enhances cytotoxic
T-cell responses against tumor cells and inhibits tumor cell growth. VISTA, mainly
expressed on hematopoietic cells, plays a key role in immunosuppression.;
UNII : 1UI8F5IIZ4;
CAS number : 1969313-51-6;
Molecule name : JNJ 61610588; JNJ-61610588; CI 8993; CI-8993;
Semantic type(s)