Preferred Label : Omidubicel;
NCIt synonyms : Ex Vivo-expanded Umbilical Cord Blood-derived Hematopoietic CD34-positive Progenitor
Cells; UCB-derived CD34 HPCs; Omidubicel-onlv;
NCIt definition : A population of cryopreserved, ex vivo expanded and nicotinamide (NAM)-treated, CD34-positive
hematopoietic progenitor cells (HPCs) derived from allogeneic, CD34 cells isolated
from human umbilical cord blood (UCB) that can be used during transplantation. CD34
HPCs were isolated from human UCB mononuclear cells, and expanded ex vivo. Upon transplantation
with omidubicel, these cells can differentiate into a variety of cell types including
fibroblasts, osteoblasts, chondrocytes, myocytes, adipocytes, and endothelial cells.
Compared to bone marrow transplants, these HPCs have decreased risk of causing graft-versus
host disease (GvHD), increased survival, and enhanced transplant and engraftment potential
for any given patient as there is no need for a matched donor. Compared to untreated
HPCs, treating the cells ex vivo with NAM increases the number of HPCs from UCB, enhances
migration, bone marrow (BM) homing, engraftment and increases neutrophil and platelet
recovery.;
UNII : ET4JC4S66E;
Drug name : NiCord; Omisirge;
NCI Metathesaurus CUI : CL507909;
Origin ID : C127119;
UMLS CUI : C4288077;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
