Preferred Label : Autologous Neuroblastoma Lysate/KLH-pulsed Dendritic Cell Vaccine;
NCIt synonyms : Keyhole Limpet Hemocyanin-pulsed Dendritic Cell Vaccine; Autologous Neuroblastoma Lysate/KLH-pulsed DC Vaccine;
NCIt definition : A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with
a cell lysate from an autologous neuroblastoma containing tumor-associated antigens
(TAAs) and the immunostimulant keyhole limpet hemocyanin (KLH), with potential immunostimulatory
and antineoplastic activities. Upon administration, autologous neuroblastoma lysate/KLH-pulsed
DC vaccine may stimulate the immune system to mount an anti-tumoral cytotoxic T-lymphocyte
(CTL) response against neuroblastoma cells, which may result in tumor cell lysis.
KLH is an immunogenic carrier and serves as an immunostimulant to improve antigenic
immune recognition and T-cell responses.;
NCI Metathesaurus CUI : CL507905;
Origin ID : C127115;
UMLS CUI : C4289950;
Semantic type(s)
- concept_is_in_subset
