Uterine Corpus Malignant PEComa

Preferred Label : Uterine Corpus Malignant PEComa;

NCIt synonyms : Malignant Uterine Corpus Perivascular Epithelioid Cell Tumor; Malignant Uterine Corpus PEComa; Uterine Corpus Malignant Perivascular Epithelioid Cell Tumor;

NCIt definition : A malignant neoplasm with perivascular epithelioid cell differentiation arising from the uterine corpus. The neoplasm is usually a large size, and charcaterized by the presence of marked nuclear atypia, pleomorphism, increased mitotic activity, necrosis, and infiltrative margins. The most common metastatic sites are lungs, lymph nodes, and bone. Patients present with a pelvic mass or abnormal bleeding.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL508057;

Details

Origin ID

C127072;

UMLS CUI

C4288774;

Disease may have findings
- Aggressive Clinical Course [NCIt concept]
Excludes anatomical site(s)
- Bone [NCIt concept]
Has associated anatomic sites
- Connective and Soft Tissue [NCIt concept]
- Corpus Uteri [NCIt concept]
- Female Reproductive System [NCIt concept]
- Genitourinary System [NCIt concept]
- Reproductive System [NCIt concept]
- Uterus [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Indolent Clinical Course [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Perivascular Epithelioid Cell [NCIt concept]
disease_has_finding
- Cellular Pleomorphism [NCIt concept]
- HMB-45-Positive Neoplastic Cells Present [NCIt concept]
- High Mitotic Activity [NCIt concept]
- Infiltrative Growth Pattern [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Marked Nuclear Atypia Present [NCIt concept]
- Metastatic/Recurrent Disease [NCIt concept]
- Necrotic Change [NCIt concept]
- Perivascular Arrangement of Tumor Cells [NCIt concept]
- S-100-Positive Neoplastic Cells Present [NCIt concept]
- Tissue Differentiation Uncertain [NCIt concept]
disease_has_normal_tissue_origin
- Soft Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Corpus Uteri [NCIt concept]
- Female Reproductive System [NCIt concept]
disease_mapped_to_gene
- TSC2 Gene [NCIt concept]
disease_may_have_abnormal_cell
- Neoplastic Spindle Cell [NCIt concept]
disease_may_have_associated_disease
- Tuberous Sclerosis [NCIt concept]
disease_may_have_molecular_abnormality
- TSC2 Gene Mutation [NCIt concept]

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