" /> MBP wt Allele - CISMeF





Preferred Label : MBP wt Allele;

NCIt synonyms : Myelin A1 Protein, Basic Gene; Myelin Basic Protein wt Allele;

NCIt definition : Human MBP wild-type allele is located in the vicinity of 18q23 and is approximately 155 kb in length. This allele, which encodes myelin basic protein, is involved in neuronal development and myelination.;

NCIt note : The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, longer mRNAs are also present in the bone marrow and the immune system; they arise from the long MBP gene (Golli-MBP) that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli or the classic MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain the 3 Golli-MBP exons, spliced in-frame to 1 or more MBP exons. The second family of transcripts contain only MBP exons and produce the classic myelin basic protein isoforms. (EntrezGene);

NCI Metathesaurus CUI : CL508038;

GenBank Accession Number : NM_001025081;

Details


You can consult :


Nous contacter.
01/06/2025


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.