NCIt definition : Human MBP wild-type allele is located in the vicinity of 18q23 and is approximately
155 kb in length. This allele, which encodes myelin basic protein, is involved in
neuronal development and myelination.;
NCIt note : The protein encoded by the classic MBP gene is a major constituent of the myelin sheath
of oligodendrocytes and Schwann cells in the nervous system. However, longer mRNAs
are also present in the bone marrow and the immune system; they arise from the long
MBP gene (Golli-MBP) that contains 3 additional exons located upstream of the classic
MBP exons. Alternative splicing from the Golli or the classic MBP transcription start
sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli
mRNAs contain the 3 Golli-MBP exons, spliced in-frame to 1 or more MBP exons. The
second family of transcripts contain only MBP exons and produce the classic myelin
basic protein isoforms. (EntrezGene);