Preferred Label : 2'-5'-Oligoadenylate;
NCIt synonyms : 2'-5' Oligoadenylate; 2-5A;
NCIt related terms : 2-5-Oligoadenylate;
NCIt definition : An oligonucleotide synthesized from adenosine triphosphate (ATP) by enzymes in the
2'-5'-oligoadenylate synthase family. The production of 2'-5'-oligoadenylate is stimulated
by the presence of double stranded RNA (dsRNA) and binds to inactive monomeric forms
of ribonuclease L (RNase L), thereby promoting RNase L dimerization and activation.
Active RNase L degrades both cellular and viral RNAs, which inhibits protein translation
and leads to the abrogation of viral replication. 2'-5'-oligoadenylates play a key
role in the innate immunity against viruses.;
Origin ID : C126910;
UMLS CUI : C0045143;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
