NCIt definition : A mouse monoclonal antibody that recognizes the soluble caspase-cleaved (cc) form
of human keratin, type I cytoskeletal 18 (cytokeratin 18, K18, KRT18, CK18). Monoclonal
antibody M30 binds to a neo-epitope (NE) exposed after caspase cleavage after the
aspartic acid residue at position 396 of K18 (K18Asp396). This neo-epitope results
from the proteolytic activity of caspase-3, -7 or -9, which are active during apoptosis.
Thus, M30 can be used to indirectly identify caspase activation and to determine if
the cell death in a sample is due to apoptosis rather than necrosis.;
Semantic type(s)